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Clinical Chemistry 25: 1296-1300, 1979;
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Clinical Chemistry, Vol 25, 1296-1300, Copyright © 1979 by American Association for Clinical Chemistry

Analysis for diazepam and nordiazepam by electron-capture gas chromatography and by liquid chromatography

JE Wallace, HA Schwertner and EL Shimek Jr

We describe the use of electron-capture gas chromatography or reversed- phase "high-performance" liquid chromatography for concurrent analysis for diazepam and nordiazepam in serum. In the gas-chromatographic analysis our use of a new chemically deactivated stationary liquid phase, SP 2250-DB (Supelco, Inc.), resulted in improved chromatographic sensitivity and peak symmetry for the two benzodiazepines as compared to that obtained with either OV-17or OV-1 phases. Steady-state concentrations of diazepam and nordiazepam in serum as determined by gas-liquid chromatography correlated closely with those found by liquid- liquid chromatography.




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