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Clinical Chemistry 25: 1384-1387, 1979;
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Clinical Chemistry, Vol 25, 1384-1387, Copyright © 1979 by American Association for Clinical Chemistry

D-Mannose in human serum, measured as its aldononitrile acetate derivative

TP Monson and KP Wilkinson

We report a procedure for determining D-mannose in serum. After removal of proteins and lipids, the carbohydrate-containing fraction is treated to form the aldononitrile acetate derivative and analyzed by gas-- liquid chromatography with a flame-ionization detector. D-Mannose and D- glucose had retention times of 31 and 34 min, respectively. Day-to-day reproducibilities (CV) of between 2 and 12% for mannose were attainable for quantities of 100--900 ng. Related hexoses and derivatives do not interfere. The sensitivity was such that 10 mg/L could be detected in a 0.1-mL sample of serum. This method may be of use in diagnosing invasive Candida infection.




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Copyright © 1979 by the American Association for Clinical Chemistry.