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Clinical Chemistry 25: 1459-1460, 1979;
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Clinical Chemistry, Vol 25, 1459-1460, Copyright © 1979 by American Association for Clinical Chemistry

Heparin interferes with albumin determination by dye-binding methods

P Bonvicini, G Ceriotti, M Plebani and G Volpe

Heparin, when added in vitro at rather high concentrations (400--1000 kilounits/L) as an anticoagulant, interferes with albumin determination by bromcresol green by forming an insoluble precipitate with this dye. The interference is much less with bromcresol purple. It can be abolished by addition of hexadimethrine bromide.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
B. S. Karon, K. C. Kempe, and M. G. Scott
Heparin Interference with Sodium and Albumin Assays
Clin. Chem., April 1, 1997; 43(4): 697 - 698.
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