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Clinical Chemistry 26: 117-119, 1980;
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Clinical Chemistry, Vol 26, 117-119, Copyright © 1980 by American Association for Clinical Chemistry

Liquid-chromatographic determination of 5-fluorocytosine

JO Miners, T Foenander and DJ Birkett

We report a "high-performance" liquid-chromatographic method for measuring 5-fluorocytosine in plasma and cerebrospinal fluid. After deproteinization with trichloroacetic acid, the supernates are chromatographed on a reversed-phase (C18) column. Response to concentration is linear in the range of 5 to 200 mg/L, with ultraviolet detection at 276 nm. The assay requires only 0.1 mL of plasma, is reproducible, and may be performed in less than 12 min. 5- Fluorocytosine concentrations determined by this procedure correlated well with those obtained by spectrofluorometry, although the present method is more specific with no observable interference from co- administered amphotericin B and most other commonly encountered drugs, including salicylat:. This method is applicable to the routine therapeutic monitoring of pediatric and adult patients as well as to pharmacokinetic studies.


The following articles in journals at HighWire Press have cited this article:


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 J Antimicrob ChemotherHome page
P. H. J. van der Voort, E. C. Boerma, and J. P. Yska
Serum and intraperitoneal levels of amphotericin B and flucytosine during intravenous treatment of critically ill patients with Candida peritonitis
J. Antimicrob. Chemother., May 1, 2007; 59(5): 952 - 956.
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Copyright © 1980 by the American Association for Clinical Chemistry.