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Clinical Chemistry 26: 1741-1744, 1980;
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Clinical Chemistry, Vol 26, 1741-1744, Copyright © 1980 by American Association for Clinical Chemistry

Bence Jones myeloma with a tetramer of kappa-type globulin in serum

ML Gallango, R Suinaga and M Ramirez

We describe a case of Bence Jones multiple myeloma involving two kappa- type monoclonal proteins. One was isolated from serum, the other from both serum and urine. After biochemical and immunochemical analyses, we concluded that one of the proteins was a tetramer, present in serum but not in urine, whereas the other was a monomer, which was excreted in large amounts in the urine during the terminal stage of the disease.




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