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Clinical Chemistry 26: 1137-1139, 1980;
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Clinical Chemistry, Vol 26, 1137-1139, Copyright © 1980 by American Association for Clinical Chemistry

Effect of cations on the human creatine kinase isoenzymes

DA Nealon and AR Henderson

We report our findings on the effect of Ca2+, K+, Na+, Fe2+, Mn2+, Zn2+, and Cu2+ on the activity of creatine kinase isoenzymes derived from human tissues. The only inhibitory cation was Ca2+, and Dixon plots of the data indicate the inhibition to be competitive for the Mg2+ in the reaction assay mixture. This effect of Ca2+ on all three isoenzymes is completely reversed by including Mg2+ (10 mmol/L) and ethylenediaminetetraacetate (2 mmol/L) in the assay mixture. Our findings suggest that it is unnecessary to add chelators to the patient's sample.


The following articles in journals at HighWire Press have cited this article:


Home page
 Mol. Pathol.Home page
N Durany, J Carreras, M Valenti, J Camara, and J Carreras
Inactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum
Mol. Pathol., August 1, 2002; 55(4): 242 - 249.
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