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Clinical Chemistry 27: 1300-1302, 1981;
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Clinical Chemistry, Vol 27, 1300-1302, Copyright © 1981 by American Association for Clinical Chemistry

Charcoal hemoperfusion for treatment of carbamazepine poisoning

KM Chan, JJ Aguanno, R Jansen and DN Dietzler

We report a case of carbamazepine (Tegretol) poisoning that was treated with charcoal hemoperfusion. When admitted, the patient was comatose and required ventilatory support. Hemoperfusion with coated activated charcoal successfully decreased her serum carbamazepine concentration from 60 mg/L to 36 mg/L within 2 h, with subsequent clinical improvement. Approximately 39 h would have been required to obtain this decrease via the patient's inherent elimination rate. Activated charcoal hemoperfusion may be useful as an adjunctive therapy for patients in advanced comatose states with associated respiratory depression and potentially fatal outcome.


The following articles in journals at HighWire Press have cited this article:


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 The Annals of PharmacotherapyHome page
Y. Lurie, Y. Bentur, Y. Levy, E. Baum, and N. Krivoy
Limited Efficacy of Gastrointestinal Decontamination in Severe Slow-Release Carbamazepine Overdose
Ann. Pharmacother., September 1, 2007; 41(9): 1539 - 1543.
[Abstract] [Full Text] [PDF]

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 Hum Exp ToxicolHome page
D.W. Denning, L. Matheson, S.M. Bryson, J. Streete, D.J. Berry, and J.A. Henry
Death Due to Carbamazepine Self-poisoning: Remedies Reviewed
Human and Experimental Toxicology, May 1, 1985; 4(3): 255 - 260.
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