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Clinical Chemistry 28: 25-28, 1982;
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Clinical Chemistry, Vol 28, 25-28, Copyright © 1982 by American Association for Clinical Chemistry

Quantitation of urinary normetanephrine and metanephrine by reversed- phase extraction and mass-fragmentographic analysis

C Canfell, SR Binder and H Khayam-Bashi

Hydrolyzed urine with added ring-trideuterated normetanephrine and metanephrine is applied to wet C18-reversed-phase minicolumns. The "metanephrines" are eluted, dried, derivatized with pentafluoropropionic anhydride, and analyzed with the gas chromatograph- mass spectrometer. Ions for the nondeuterated and trideuterated compounds are monitored at ml z 458 and 461, respectively. For both normetanephrine and metanephrine, the standard curve is linear over the range 10-2000 micrograms/L and the procedure has adequate precision both within-run (CV less than 3%) and between-day (CV less than 7%). Alkaline pH in the extraction is important for optimal analytical recovery. We have examined the potential value of untimed urine specimens for screening purposes and compared 24-h urine concentrations of these analyses in normotensive and hypertensive persons.


The following articles in journals at HighWire Press have cited this article:


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R. J. Singh, S. K. Grebe, B. Yue, A. L. Rockwood, J. C. Cramer, Z. Gombos, G. Eisenhofer, and S. Binder
Precisely Wrong? Urinary Fractionated Metanephrines and Peer-Based Laboratory Proficiency Testing * A representative for Bio-Rad responds:
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R. L. Taylor and R. J. Singh
Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Analysis of Urinary Conjugated Metanephrine and Normetanephrine for Screening of Pheochromocytoma
Clin. Chem., March 1, 2002; 48(3): 533 - 539.
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D. K. Crockett, E. L. Frank, and W. L. Roberts
Rapid Analysis of Metanephrine and Normetanephrine in Urine by Gas Chromatography-Mass Spectrometry
Clin. Chem., February 1, 2002; 48(2): 332 - 337.
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Copyright © 1982 by the American Association for Clinical Chemistry.