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Clinical Chemistry 28: 45-49, 1982;
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Clinical Chemistry, Vol 28, 45-49, Copyright © 1982 by American Association for Clinical Chemistry

Characterization of uremic "middle molecular" fractions by gas chromatography, mass spectrometry, isotachophoresis, and liquid chromatography

AC Schoots, FE Mikkers, HA Claessens, R De Smet, N Van Landschoot and SM Ringoir

Uremic ultrafiltrates (and normal serum, for comparison) were fractionated by means of gel filtration. The collected fractions were further investigated by combined analytical techniques: "high- performance" liquid chromatography, gas chromatography, mass spectrometry, and isotachophoresis. Ultrafiltrate fractions in the so- called middle molecular mass region (Mr 500-2000) contained a considerable amount of substances of low molecular mass, such as carbohydrates, organic acids, amino acids, and ultraviolet absorbing solutes. Ultraviolet absorbance in the "middle molecular mass region" of the gel chromatogram is mainly due to the presence of these rather low-molecular-mass solutes. Therefore this signal is not a quantitative measure of molecules with a "middle" molecular mass.




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Copyright © 1982 by the American Association for Clinical Chemistry.