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Clinical Chemistry 28: 2414-2417, 1982;
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Clinical Chemistry, Vol 28, 2414-2417, Copyright © 1982 by American Association for Clinical Chemistry

Transformation of creatine kinase-BB isoenzyme in vitro: effect of carboxylic acids, thiols, pH, cations, and chelators

JA Lott and JW Heinz

Creatine kinase isoenzyme BB from rat brain was incubated with serum, dialyzed serum, or plasma, with added carboxylic acids, thiols, buffers, or cations. It was found to be very unstable at 37 degrees C under all these conditions, being transformed to CK-BB', a form that migrates like CK-MB on agarose electrophoretic plates. This transformation is enhanced at alkaline pH and, especially, by Zn2+. CK- BB' is quite stable, and probably results from binding of cations to CK- BB, because the transformation is prevented by EDTA and citrate.


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Home page
 Mol. Pathol.Home page
N Durany, J Carreras, M Valenti, J Camara, and J Carreras
Inactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum
Mol. Pathol., August 1, 2002; 55(4): 242 - 249.
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