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Clinical Chemistry 28: 291-293, 1982;
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Clinical Chemistry, Vol 28, 291-293, Copyright © 1982 by American Association for Clinical Chemistry

A candidate reference method for uric acid in serum. II. Interlaboratory testing

P Duncan, N Gochman, D Bayse, R Burnett, N Carey, R Carter, WD Fellows, C Garber, G Kessler, R McComb, W Miller, P Nast, W Ryan, R Schaffer, B Tejeda, R Vanderlinde and G Widdowson

We describe the interlaboratory testing of a candidate Reference Method (Part I) for uric acid in serum. The method is based on the ultrasound spectrophotometric quantitation of uric acid before and after incubation with uricase. A comprehensive investigation involving 12 laboratories was organized to document the transferability, intra- and interlaboratory precision, and general reliability of the candidate Reference Method. The interlaboratory CV with this method was about 2 to 6% for uric acid concentrations ranging from 0.12 to 0.60 mmol/L. The results detailed here demonstrate that the method can be successfully duplicated among different laboratories.




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Copyright © 1982 by the American Association for Clinical Chemistry.