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Clinical Chemistry 28: 861-866, 1982;
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Clinical Chemistry, Vol 28, 861-866, Copyright © 1982 by American Association for Clinical Chemistry

Design and implementation of a prototype Human Protein Index

J Taylor, NL Anderson, AE Scandora Jr, KE Willard and NG Anderson

This paper describes information-handling aspects of the TYCHO I analysis system (Clin, Chem. 27: 1807--1820, 1981), which analyzes two- dimensional electrophoresis gels, matches the individual protein spots with those in a reference pattern, and stores various information-- including spot measurements, identifications, treatment profiles, set memberships, and comments--in a computerized database. This and additional information such as amino acid composition and cellular localization is then accessible from an interactive program that includes a pictorial user interface and presents much of the data in graphical form. Use of the TYCHO I system is illustrated by examples drawn from analyses of gel patterns from human leukocytes.


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Copyright © 1982 by the American Association for Clinical Chemistry.