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Clinical Chemistry 28: 1153-1158, 1982;
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Clinical Chemistry, Vol 28, 1153-1158, Copyright © 1982 by American Association for Clinical Chemistry

Influence of triglyceride-rich lipoproteins on nephelometry of apolipoprotein A-I

H Funke and G Assmann

Measurement of apolipoprotein A-I in native human sera by endpoint or rate nephelometry may give falsely high results for sera that have a high triglyceride content. Such erroneous determinations of apolipoprotein A-I can be avoided if one instead assays supernates of sera from which apolipoprotein B-containing particles have been precipitated with phosphotungstic acid and MgCl2. A high triglyceride concentration in serum does not impair the completeness of the precipitation of apolipoprotein B-containing lipoproteins or the analytical recovery of apolipoprotein A-I. In a prospective epidemiologic study, by using rate nephelometry we found that there were different mean concentrations for apolipoprotein A-I in supernates of sera from men (1.36 g/L) and women (1.49 g/L). Furthermore, the known risk factors for atherosclerosis showed different correlations with apolipoprotein A-I than with high-density lipoprotein cholesterol.


The following articles in journals at HighWire Press have cited this article:


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 J. Lipid Res.Home page
E. Campos, L. Kotite, P. Blanche, Y. Mitsugi, P. H. Frost, U. Masharani, R. M. Krauss, and R. J. Havel
Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma
J. Lipid Res., March 1, 2002; 43(3): 365 - 374.
[Abstract] [Full Text] [PDF]


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Copyright © 1982 by the American Association for Clinical Chemistry.