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Clinical Chemistry 29: 466-469, 1983;
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Clinical Chemistry, Vol 29, 466-469, Copyright © 1983 by American Association for Clinical Chemistry

Effect of aspirin on determinations of glycosylated hemoglobin

DM Nathan, TB Francis and JL Palmer

We investigated the in vivo and in vitro effects of aspirin on several clinical assays of glycosylated hemoglobin. Acetylation of hemoglobin falsely increased the glycosylated hemoglobin fraction measured by "high-performance" liquid chromatography and electrophoresis, but isoelectric focusing and colorimetric techniques differentiated between acetylated and glycosylated fractions. Aspirin ingestion may result in an apparent increase in glycosylated hemoglobin measured with common clinical assays.


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Copyright © 1983 by the American Association for Clinical Chemistry.