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Clinical Chemistry 32: 624-628, 1986;
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Clinical Chemistry, Vol 32, 624-628, Copyright © 1986 by American Association for Clinical Chemistry

Lactate dehydrogenase isoenzyme-1/total ratio: accurate for determining the existence of myocardial infarction

J Adan, LH Bernstein and J Babb

We have gradually revised our medical protocols for measuring creatine kinase MB isoenzyme (CK-MB) and lactate dehydrogenase isoenzyme-1 (LD- 1) because of identifiable problems in the use of an interpretation of CK-MB isoenzyme associated with slowly evolving or small myocardial infarct, the use of thrombolytic therapy, or burn and trauma, each of which affects the rate of appearance and composition of isoenzymes present. Despite recent evidence of the efficacy of LD-1 isoenzyme measurement in the first 12 to 24 h of myocardial infarction, this test is not widely used because of overstated assumptions about the value of CK-MB. Here we studied the adequacy of the current isoenzyme assays by determining the value of CK-MB and LD-1 at optimum serum sampling times and establishing the contribution of individual and combined predictors to diagnostic efficiency. We conclude that the LD-1/total LD activity ratio in serum is superior to measurement of CK-MB or LD-1, or both, in the diagnosis of acute myocardial infarction. Moreover, this ratio is most valuable when interpretation of the result for CK-MB isoenzyme is equivocal in patients with small or evolving myocardial infarcts.


The following articles in journals at HighWire Press have cited this article:


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 ANGIOLOGYHome page
P. C. Painter, S. Van Meter, R. L. Dabbs, and G. E. Clement
Analytical Evaluation and Comparison of Dupont aca(R) Lactate Dehydrogenase-1 (LD1) Isoenzyme Assay Diagnostic Efficiency for Acute Myocardial Infarction Detection with Other LD1 Methods and aca@ CK-MB: A Two-Site Study
Angiology, July 1, 1994; 45(7): 585 - 595.
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Copyright © 1986 by the American Association for Clinical Chemistry.