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Clinical Chemistry 32: 706-708, 1986;
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Clinical Chemistry, Vol 32, 706-708, Copyright © 1986 by American Association for Clinical Chemistry

Complex biochemical syndrome of hypocalcemia and hypoparathyroidism during cytotoxic treatment of an infant with leukemia

J Wandrup and C Kancir

Patients with cancer are especially vulnerable to the development of hyper- and hypocalcemia. These disorders may be the basic clinical manifestation of cancer or may result from vigorous cancer treatment. During cytotoxic treatment of a child with leukemia we describe the longitudinal course of ionized calcium in a complex syndrome of hypocalcemia and hypoparathyroidism. The results suggest that the development of severe hypocalcemia can be explained on the basis of hypoparathyroidism in relation to hyperphosphatemia, hypomagnesemia, and acute renal failure. The low ionized calcium was unsuccessfully treated with several doses of calcium levulinate but successfully treated with 1 alpha-hydroxycholecalciferol.




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Copyright © 1986 by the American Association for Clinical Chemistry.