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Clinical Chemistry 32: 805-807, 1986;
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Clinical Chemistry, Vol 32, 805-807, Copyright © 1986 by American Association for Clinical Chemistry

Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients

DS Abdalla, HP Monteiro, JA Oliveira and EJ Bechara

Activities of superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) in erythrocytes were evaluated in 50 schizophrenic and 20 manic-depressive patients, who were or were not being treated with different neuroleptic drugs, and results were compared with those for 58 normal individuals. Neuroleptic-treated and untreated schizophrenic patients showed similar activities of superoxide dismutase, about 60% higher than those found in normal individuals (p less than 0.001). In manic-depressive patients treated with either lithium (n = 8) or lithium plus neuroleptic drugs (n = 12), superoxide dismutase activities were increased by about 40% over those of normal subjects (p less than 0.001). Significantly abnormal activities of glutathione peroxidase were found only in the sub-group of schizophrenic women. These results are interpreted in terms of active oxygen species involvement in the psychiatric manifestations.


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