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Clinical Chemistry 32: 1010-1012, 1986;
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Clinical Chemistry, Vol 32, 1010-1012, Copyright © 1986 by American Association for Clinical Chemistry

Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid

JD Berg, IM Chesner, RA Allen-Narker, BM Buckley and N Lawson

We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]- PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.




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Copyright © 1986 by the American Association for Clinical Chemistry.