Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 32: 1734-1737, 1986;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bookbinder, M. J.
Right arrow Articles by Panosian, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bookbinder, M. J.
Right arrow Articles by Panosian, K. J.

Clinical Chemistry, Vol 32, 1734-1737, Copyright © 1986 by American Association for Clinical Chemistry

Correct and incorrect estimation of within-day and between-day variation

MJ Bookbinder and KJ Panosian

Between-day variance is an ambiguous term representing either total variance or pure between-day variance. In either case, it is often incorrectly calculated even though analysis of variance (ANOVA) and other excellent methods of estimation are available. We used statistical theory to predict the magnitude of error expected from using several intuitive approaches to estimation of variance components. We also evaluated the impact of estimating the total population variance instead of pure between-day variance and the impact of using biased estimators. We found that estimates of variance components could be systematically biased by several hundred percent. On the basis of these results, we make recommendations to remove these biases and to standardize precision estimates.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Association for Clinical Chemistry.