Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 34: 1960-1965, 1988;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Loughlin, J. F.
Right arrow Articles by Henderson, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Loughlin, J. F.
Right arrow Articles by Henderson, A. R.

Clinical Chemistry, Vol 34, 1960-1965, Copyright © 1988 by American Association for Clinical Chemistry

Diagnostic efficiency of four lactate dehydrogenase isoenzyme-1 ratios in serum after myocardial infarction

JF Loughlin, PM Krijnen, G Jablonsky, FY Leung and AR Henderson
Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Canada.

We compared the diagnostic efficacy of the ratios LD-1/LD-2, LD-1/LD-3, LD-1/LD-4, and LD-1/LD-5 in 69 documented cases of myocardial infarction. We used 149 patients with congestive heart failure and 67 patients with nonmyocardial infarct as controls. We used a computer program to produce receiver-operating characteristic curves, decision threshold plots, and likelihood ratios for these LD ratios at 6-h intervals up to 108 h after the onset of chest pain or hospital admission. All ratios in the myocardial infarction cases peaked around 36 h after the onset of chest pain, while those for the nonmyocardial and congestive cardiac failure cases did not change over the 108-h period. In all patients with infarctions, LD-1/LD-4 and LD-1/LD-5 increased by 1.7 times (when LD-1 was less than 40%) and 3.4 times (when LD-1 was greater than 40%), respectively, over control values. Optimum decision threshold values were obtained at 13-24 h (LD-1/LD-5), 31-36 h (LD-1/LD-4 and LD-1/LD-3), and 55-60 h (LD-1/LD-2) after onset of symptoms. The highest likelihood ratio was obtained with the LD-1/LD- 4 ratio; therefore, we suggest that this is a better diagnostic test for myocardial infarction than LD-1/LD-2.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American Association for Clinical Chemistry.