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Clinical Chemistry 34: 2114-2117, 1988;
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Clinical Chemistry, Vol 34, 2114-2117, Copyright © 1988 by American Association for Clinical Chemistry

Comparison of the compression strength of human vertebral bodies with the mass and density of apatite: a study by 31P NMR spectroscopy

CE Brown, R Srinivasan, P Sigmann, JB Myklebust and JH Battocletti
Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226.

The force needed to fracture individual human thoracic and lumbar vertebral bodies is compared with the mass and density of apatite. 31P NMR spectrometry was used to quantify the apatite, because it permits the mineral content of bone to be determined noninvasively with minimal nonspecific interference from the organic matrix or from variations in composition of the marrow. Experiments were performed with bones of similar structure and function from a single individual with no history of trabecular fractures, to compensate for the effects of the other variables that affect bone strength. The coefficient of correlation between compression strength and the volume density (i.e., g/cm3) of apatite was 0.95. The correlation of strength with the mass (i.e., grams) of apatite in a vertebral body also was reasonably good, r = 0.82, but correlations with areal density (i.e., g/cm2) and linear density (i.e., g/cm) were much poorer.




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Copyright © 1988 by the American Association for Clinical Chemistry.