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Clinical Chemistry 34: 2268-2270, 1988;
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Clinical Chemistry, Vol 34, 2268-2270, Copyright © 1988 by American Association for Clinical Chemistry

Qualitative study of fecal alpha 1-proteinase inhibitor in normal subjects and patients with Crohn's disease

C Mizon, C Becuwe, M Balduyck, JF Colombel, A Cortot, J Mizon and P Degand
Laboratoire de Biochimie, Faculte de Pharmacie, Lille, France.

We applied sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting to analyze fecal alpha 1-proteinase inhibitor (alpha 1 PI) from healthy subjects and patients with Crohn's disease. A component with Mr 38,000 was characterized in normal fecal extracts as well as in six pathological samples. In these cases, the Crohn's disease activity index (CDAI), a clinical index of severity of the disease, was 170 (SEM 47). In contrast, alpha 1 PI of Mr 51,000 was detected in fecal extracts from eight patients with active Crohn's disease (CDAI = 287, SEM 39). We conclude that fecal alpha 1 PI can be considered a marker of intestinal disease activity.


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Copyright © 1988 by the American Association for Clinical Chemistry.