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Clinical Chemistry 34: 2524-2527, 1988;
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Clinical Chemistry, Vol 34, 2524-2527, Copyright © 1988 by American Association for Clinical Chemistry

Critical evaluation of the TDx Turbo Nephelometry System

BW Renoe, GL Combs, EE Coffee and RF DeGrella
Abbott Laboratories, Irving, TX 75015-2020.

We critically evaluated the Nephelometry System (TDx Turbo) for the TDx Analyzer (Turbo), as currently used for immunoglobulins (IgA, IgG, and IgM) and transferrin assays. We describe hardware, software, reagent, and procedural changes made since the original publication (Clin Chem 1985;31:1474) and the mathematical treatment of data. The unit-dose format of the reagents allows for batch or panel testing of the analytes, with a throughput of 40 tests per hour. Measurements are made at pseudo-equilibrium, with sample-blank correction. The formulation of reagents and the assay scheme are such as to eliminate the need to check these assays for antigen excess. Assay sensitivities are 3% of the standard curve ranges. CVs are 8% for all assays. The system performance, when compared with rate nephelometry and radial immunodiffusion, yielded correlation coefficients of 0.97 or better for the analytes.




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Copyright © 1988 by the American Association for Clinical Chemistry.