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Clinical Chemistry 34: 393-397, 1988;
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Clinical Chemistry, Vol 34, 393-397, Copyright © 1988 by American Association for Clinical Chemistry

Improved receptor assay for measuring digoxin activity

B Bednarczyk, SJ Soldin, I Gasinska, M D'Costa and L Perrot
Research Institute Hospital for Sick Children, Toronto, Ontario, Canada.

We describe a receptor assay of digoxin activity involving Na+/K+- ATPase (EC 3.6.1.37) derived from human heart tissue. The procedure requires 500 microL of serum or plasma and incorporates one purification step, with Sep-Pak C18 cartridges (Waters). The method appears to be considerably more specific for digoxin and its cardio- active metabolites than are conventional immunoassays. Cardio-inactive metabolites and several digoxin-like factors cross react only slightly. The between-day coefficient of variation for the procedure ranged from 8.10% to 1.37% for digoxin concentrations between 0.5 and 5.0 nmol/L.


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Copyright © 1988 by the American Association for Clinical Chemistry.