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Clinical Chemistry 34: 471-473, 1988;
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Clinical Chemistry, Vol 34, 471-473, Copyright © 1988 by American Association for Clinical Chemistry

Analytical and technical aspects of testing for drug abuse: confirmatory procedures

MA Peat
Clinical and Forensic Services, ChemWest Analytical Laboratories, Inc., Sacramento, CA.

Many laboratories are now performing urine drug testing for employers, governmental agencies, and other institutions. It is now recognized that presumptive positive screening results have to be confirmed by an analytical procedure based on a different chemical technique with greater than or equal sensitivity to the screening test. Thin-layer chromatography has been widely used for this; however, it is relatively insensitive for certain drugs, and it cannot satisfy the accuracy and precision requirements needed to determine threshold concentrations reliably. Gas chromatography-mass spectrometry is able to satisfy these threshold requirements and has become the method of choice for confirming initial immunoassay results.




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Copyright © 1988 by the American Association for Clinical Chemistry.