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Clinical Chemistry 34: 563-567, 1988;
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Clinical Chemistry, Vol 34, 563-567, Copyright © 1988 by American Association for Clinical Chemistry

Anodic stripping voltammetry procedure modified for improved accuracy of blood lead analysis

SM Roda, RD Greenland, RL Bornschein and PB Hammond
Department of Environmental Health, University of Cincinnati Medical Center, OH 45267-0056.

In evaluating the accuracy and reliability of blood lead (PbB) measurements with the Environmental Science Associates Model 3010A Trace Metal Analyzer, intralaboratory comparison demonstrated that use of the operating conditions recommended by the manufacturer resulted in consistently underestimated PbB concentrations less than 400 micrograms/L and overestimated PbB values greater than 400 micrograms/L. At PbB concentrations less than 50 micrograms/L, measured concentrations were often registered as negative results. However, these negative values could be replicated to within +/- 10 micrograms/L, indicating good precision of the method, but obviously not good accuracy. In addition, lower-than-expected lead (Pb) values were measured in samples containing increased concentrations of copper (Cu), such as may occur in pregnant women. We modified the procedure to eliminate these inaccuracies by substituting manual peak-height measurements for reliance on the integrator and digital display of the instrument. We established the accuracy of the modified procedure by using calibration standards previously quantified by isotope dilution- mass spectroscopy. A quality-control program for monitoring PbB analysis is also described.


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Pediatrics, November 1, 2007; 120(5): e1285 - e1298.
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J. D Sargent, M. A Dalton, G. T O'Connor, E. M Olmstead, and R. Z Klein
Randomized trial of calcium glycerophosphate–supplemented infant formula to prevent lead absorption
Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1224 - 1230.
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