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Clinical Chemistry 34: 761-764, 1988;
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Clinical Chemistry, Vol 34, 761-764, Copyright © 1988 by American Association for Clinical Chemistry

Comparison of Roche RIA, Roche EIA, Hybritech EIA, and Abbott EIA methods for measuring carcinoembryonic antigen

JS Nisselbaum, CA Smith, D Schwartz and MK Schwartz
Department of Clinical Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

Using 600 clinical specimens, we compared the concordance of four methods for carcinoembryonic antigen: the Roche RIA (I); the Roche EIA (II); Hybritech EIA (III); and Abbott EIA (IV). EDTA-treated plasma was used for Methods I and II and serum for Methods III and IV. However, no significant difference was found between results for serum and plasma in Method II. The normal reference interval (in micrograms/L) was I (222 specimens), 1.94 +/- 1.54; II (57 specimens), 0.8 +/- 0.5; III (100 specimens), 2.94 +/- 2.47; and IV (614 specimens), less than 5.0. The precision of all four methods was acceptable. Concordance among all of the methods exceeded 90%.




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Copyright © 1988 by the American Association for Clinical Chemistry.