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Clinical Chemistry 37: 2143-2145, 1991;
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Clinical Chemistry, Vol 37, 2143-2145, Copyright © 1991 by American Association for Clinical Chemistry

Urinary excretion of free toluenediamines in a patient with polyurethane-covered breast implants

SC Chan, DC Birdsell and CY Gradeen
Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada.

We report the detection of free 2,4-toluenediamine in urine of a patient implanted with polyurethane-covered breast implants. Samples were collected on several dates, ranging from 21 days to seven months after the insertion of the implants, and these samples all showed the presence of free 2,4-toluenediamine at a concentration of about 1 micrograms/L. The chemical was not found in a urine sample collected before implantation. This finding is important for risk assessment of cancer in patients with this type of breast implant because the chemical is a suspected carcinogen. Free 2,6-toluenediamine, an isomer, was also found in all samples from this patient.




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Copyright © 1991 by the American Association for Clinical Chemistry.