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Clinical Chemistry 37: 1580-1582, 1991;
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Clinical Chemistry, Vol 37, 1580-1582, Copyright © 1991 by American Association for Clinical Chemistry

Statistical criteria for separate reference intervals: race and gender groups in creatine kinase

EK Harris, ET Wong and ST Shaw Jr
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.

Previously published data confirming differences in creatine kinase (EC 2.7.3.2) among various race and gender subgroups in the Los Angeles area have been re-examined with use of recently proposed statistical criteria for defining separate reference intervals. Results indicate that one criterion may be too lenient, whereas another is clearly too restrictive in suggesting the need for separate intervals. Further experience with other analytes in both large and small population samples would be helpful.


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A. Lahti, P. Hyltoft Petersen, J. C. Boyd, C. G. Fraser, and N. Jorgensen
Objective Criteria for Partitioning Gaussian-distributed Reference Values into Subgroups
Clin. Chem., February 1, 2002; 48(2): 338 - 352.
[Abstract] [Full Text] [PDF]


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