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Clinical Chemistry 38: 426-431, 1992;
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Clinical Chemistry, Vol 38, 426-431, Copyright © 1992 by American Association for Clinical Chemistry

High incidence of significant urinary ascorbic acid concentrations in a west coast population--implications for routine urinalysis

ML Brigden, D Edgell, M McPherson, A Leadbeater and G Hoag
Island Medical Laboratories, Victoria, BC, Canada.

Examination of 4379 routine urinalysis specimens with dipsticks sensitive to ascorbic acid showed that 22.8% were positive specimens. The mean urinary vitamin C concentration in this population was 2120 mumol/L. There was a high rate of false-negative dipstick results for hemoglobin in patients with vitamin C in the urine. The highest false- negative rates were observed in urine samples containing less than 50 erythrocytes per high-power field. In further experiments when volunteers consumed supplemental oral USP vitamin C at doses of 100, 250, 500, and 1000 mg or vitamin C-containing fruit juices, even the lowest doses of oral vitamin C or juice resulted in sufficient urinary vitamin C to produce false-negative dipstick results in hemoglobin and glucose testing. To prevent potentially dangerous false-negative results, screening urinalysis protocols relying only on dipstick testing should include a check for urinary vitamin C or use a dipstick that is not subject to vitamin C interference.


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Copyright © 1992 by the American Association for Clinical Chemistry.