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Clinical Chemistry 38: 530-533, 1992;
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Clinical Chemistry, Vol 38, 530-533, Copyright © 1992 by American Association for Clinical Chemistry

Advanced glycosylation end products in the mesenteric artery

E MacDonald, WK Lee, S Hepburn, J Bell, PJ Scott and MH Dominiczak
Department of Biochemistry, Western Infirmary, Glasgow, Scotland, U.K.

We measured advanced glycosylation end products in the mesenteric artery of 37 patients (ages 29-82 years), 34 of whom were nondiabetic. Samples of arterial tissue were obtained during bowel resectioning. Advanced glycosylation end products were measured as collagen-linked fluorescence (excitation wavelength 370 nm, emission wavelength 440 nm) after collagenase digestion of tissue samples. Mean fluorescence of the arterial samples was 15 U/mg (range 5.3-27). Collagen fluorescence correlated with patients' age (r = 0.57; P less than 0.001). No difference in the collagen-linked fluorescence was observed between men and women (P = 0.63), hypertensive and normotensive patients (P = 0.44), smokers and nonsmokers (P = -0.52), and patients with and without symptomatic coronary heart disease (P = 0.7). This study demonstrates, for the first time, the relationship between collagen- linked fluorescence and patients' age in human arterial tissue ex vivo.


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Copyright © 1992 by the American Association for Clinical Chemistry.