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Clinical Chemistry 40: 2216-2222, 1994;
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Clinical Chemistry, Vol 40, 2216-2222, Copyright © 1994 by American Association for Clinical Chemistry

Verification of reference ranges by using a Monte Carlo sampling technique

EW Holmes, SE Kahn, PA Molnar and EW Bermes Jr
Department of Pathology, Loyola University Stritch School of Medicine, Maywood, IL 60153.

We have investigated the application of Monte Carlo significance tests to the verification of reference ranges in the context of the transfer of an established range from one laboratory to another. Here we present an introduction to the Monte Carlo technique, outline a procedure for performing these tests using a commercially available software program, and demonstrate some of the operating characteristics of the tests when they are used to compare samples of different sizes and variances.




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Copyright © 1994 by the American Association for Clinical Chemistry.