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Clinical Chemistry 40: 1522-1527, 1994;
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Clinical Chemistry, Vol 40, 1522-1527, Copyright © 1994 by American Association for Clinical Chemistry

Carboxyhemoglobin determined in neonatal blood with a CO-oximeter unaffected by fetal oxyhemoglobin

HJ Vreman and DK Stevenson
Department of Pediatrics, Stanford University School of Medicine, CA 94305-5119.

Measurements of carboxyhemoglobin (COHb) for clinical purposes are routinely made with CO-oximeters. However, fetal hemoglobin (HbF) interferes with this spectrophotometric method. The manufacturer (Ciba Corning Diagnostics) of a new CO-oximeter (CCD 270) claims that COHb measurements with this instrument are insignificantly affected by HbF. We examined this claim through CO-oximeter analysis of cord blood/adult blood mixtures and compared the results with those obtained by gas chromatography (GC). We also studied the influence of oxygen and bilirubin concentrations. Measurements of COHb with CCD 270 were significantly lower than the GC measurements, but the differences were not clinically important. Linear regression analysis of HbF and COHb measurements (n = 68) showed significant correlation (P < 0.0001) between the two factors for the older CCD 2500 CO-oximeter (R2 = 0.56), but not for the CCD 270 (R2 = 0.06) or GC (R2 = 0.02). Bilirubin concentrations, which affected COHb measurements with CCD 2500, did not significantly affect CCD 270 measurements. We conclude that COHb measurements with CCD 270 CO-oximeter are not affected by HbF or bilirubin concentrations.


The following articles in journals at HighWire Press have cited this article:


Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M. Kaplan, H. J Vreman, C. Hammerman, and D. K Stevenson
Neonatal bilirubin production, reflected by carboxyhaemoglobin concentrations, in Down's syndrome
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1999; 81(1): 56F - 60.
[Abstract] [Full Text]

Home page
 Arch Pediatr Adolesc MedHome page
H. C. Lu, R. D. Shih, S. Marcus, B. Ruck, and T. Jennis
Pseudomethemoglobinemia: A Case Report and Review of Sulfhemoglobinemia
Arch Pediatr Adolesc Med, August 1, 1998; 152(8): 803 - 805.
[Abstract] [Full Text] [PDF]


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