Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 45: 184-188, 1999;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (184)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lo, Y.M. D.
Right arrow Articles by Redman, C. W.G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lo, Y.M. D.
Right arrow Articles by Redman, C. W.G.
Related Collections
Right arrow Molecular Diagnostics and Genetics
Right arrow Endocrinology and Metabolism
Right arrow Automation and Analytical Techniques
(Clinical Chemistry. 1999;45:184-188.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia

Y.M. Dennis Lo1,a, Tse N. Leung2, Mark S.C. Tein1, Ian L. Sargent3, Jun Zhang1, Tze K. Lau2, Christopher J. Haines2 and Christopher W.G. Redman

Departments of
1 Chemical Pathology and
2 Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR.
3 Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.
a Author for correspondence. Fax 852 2194 6171; e-mail loym{at}cuhk.edu.hk.

Background: There is much recent interest in the biologic and diagnostic implication of cell-free non-host DNA in the plasma and serum of human subjects. To determine if quantitative abnormalities of circulating non-host DNA may be associated with certain pathologic processes, we used circulating fetal DNA in preeclampsia as a model system. Methods: We studied 20 preeclamptic women and 20 control subjects of comparable gestational age (means, 32 and 33 weeks, respectively). Male fetal DNA in maternal serum was measured using real-time quantitative PCR for the SRY gene on the Y chromosome. Results: The imprecision (CV) of the assay was 2.7%. The median circulating fetal DNA was increased fivefold in 20 preeclamptic women compared with 20 control pregnant women (381 vs 76 genome-equivalents/mL, P <0.001). Conclusions: These observations suggest that preeclampsia is associated with disturbances in the liberation and/or clearance mechanisms of circulating DNA. These results also raise the possibility that measurement of circulating DNA may prove useful as a marker for the diagnosis and/or monitoring of preeclampsia.




The following articles in journals at HighWire Press have cited this article:


Home page
 Am. J. Pathol.Home page
A. F. Orozco, C. J. Jorgez, C. Horne, D. A. Marquez-Do, M. R. Chapman, J. R. Rodgers, F. Z. Bischoff, and D. E. Lewis
Membrane Protected Apoptotic Trophoblast Microparticles Contain Nucleic Acids: Relevance to Preeclampsia
Am. J. Pathol., December 1, 2008; 173(6): 1595 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C. F. Wright and H. Burton
The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis
Hum. Reprod. Update, October 22, 2008; (2008) dmn047v1.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. M. F. Lun, R. W. K. Chiu, K. C. Allen Chan, T. Yeung Leung, T. Kin Lau, and Y. M. Dennis Lo
Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma
Clin. Chem., October 1, 2008; 54(10): 1664 - 1672.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
J. F. Smith and Y. Blumenfeld
Cell-free Fetal DNA in Maternal Plasma: Progress and Potential
NeoReviews, August 1, 2008; 9(8): e332 - e337.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y. K. Tong, C. Ding, R. W.K. Chiu, A. Gerovassili, S. S.C. Chim, T. Y. Leung, T. N. Leung, T. K. Lau, K. H. Nicolaides, and Y.M. D. Lo
Noninvasive Prenatal Detection of Fetal Trisomy 18 by Epigenetic Allelic Ratio Analysis in Maternal Plasma: Theoretical and Empirical Considerations
Clin. Chem., December 1, 2006; 52(12): 2194 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.C. A. Chan, C. Ding, A. Gerovassili, S. W. Yeung, R. W.K. Chiu, T. N. Leung, T. K. Lau, S. S.C. Chim, G. T.Y. Chung, K. H. Nicolaides, et al.
Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis
Clin. Chem., December 1, 2006; 52(12): 2211 - 2218.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A M Stevens
Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?
Lupus, November 1, 2006; 15(11): 820 - 826.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
M. L. Tjoa, T. Cindrova-Davies, O. Spasic-Boskovic, D. W. Bianchi, and G. J. Burton
Trophoblastic Oxidative Stress and the Release of Cell-Free Feto-Placental DNA
Am. J. Pathol., August 1, 2006; 169(2): 400 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.C. A. Chan, A. B.Y. Hui, N. Wong, T. K. Lau, T. N. Leung, K.-W. Lo, and Y.M. D. Lo
Investigation of the Genomic Representation of Plasma DNA in Pregnant Women by Comparative Genomic Hybridization Analysis: A Feasibility Study
Clin. Chem., December 1, 2005; 51(12): 2398 - 2401.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. S. C. Chim, Y. K. Tong, R. W. K. Chiu, T. K. Lau, T. N. Leung, L. Y. S. Chan, C. B. M. Oudejans, C. Ding, and Y. M. D. Lo
Detection of the placental epigenetic signature of the maspin gene in maternal plasma
PNAS, October 11, 2005; 102(41): 14753 - 14758.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
X. Y. Zhong, S. Gebhardt, R. Hillermann, K. C. Tofa, W. Holzgreve, and S. Hahn
Parallel Assessment of Circulatory Fetal DNA and Corticotropin-Releasing Hormone mRNA in Early- and Late-Onset Preeclampsia
Clin. Chem., September 1, 2005; 51(9): 1730 - 1733.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. Zimmermann, A. El-Sheikhah, K. Nicolaides, W. Holzgreve, and S. Hahn
Optimized Real-Time Quantitative PCR Measurement of Male Fetal DNA in Maternal Plasma
Clin. Chem., September 1, 2005; 51(9): 1598 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.C. A. Chan, S.-W. Yeung, W.-B. Lui, T. H. Rainer, and Y.M. D. Lo
Effects of Preanalytical Factors on the Molecular Size of Cell-Free DNA in Blood
Clin. Chem., April 1, 2005; 51(4): 781 - 784.
[Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y.M. D. Lo
Recent Advances in Fetal Nucleic Acids in Maternal Plasma
J. Histochem. Cytochem., March 1, 2005; 53(3): 293 - 296.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
T.V. Zolotukhina, N.V. Shilova, and E. Y. Voskoboeva
Analysis of Cell-free Fetal DNA in Plasma and Serum of Pregnant Women
J. Histochem. Cytochem., March 1, 2005; 53(3): 297 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. Mavrou, A. Kolialexi, A. Souka, A. Pilalis, Y. Kavalakis, P. Antsaklis, E. Kanavakis, and A. Antsaklis
First-trimester NRBC Count in Maternal Circulation: Correlation with Doppler Ultrasound Studies
J. Histochem. Cytochem., March 1, 2005; 53(3): 315 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. Fernandez, B. Prieto, A. Escudero, J. H. Ladenson, and F. V. Alvarez
A Monoclonal Antibody with Potential for Aiding Non-invasive Prenatal Diagnosis: Utility in Screening of Pregnant Women at Risk of Preeclampsia
J. Histochem. Cytochem., March 1, 2005; 53(3): 345 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
X. Y. Zhong, W. Holzgreve, I. Hoesli, and S. Hahn
Circulatory Corticotropin-Releasing Hormone mRNA Concentrations Are Increased in Women with Preterm Delivery But Not in Those Who Respond to Tocolytic Treatment
Clin. Chem., March 1, 2005; 51(3): 635 - 636.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. K. R. Chinnapapagari, W. Holzgreve, O. Lapaire, B. Zimmermann, and S. Hahn
Treatment of Maternal Blood Samples with Formaldehyde Does Not Alter the Proportion of Circulatory Fetal Nucleic Acids (DNA and mRNA) in Maternal Plasma
Clin. Chem., March 1, 2005; 51(3): 652 - 655.
[Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Jiang and D. S. Pisetsky
The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum
J. Leukoc. Biol., March 1, 2005; 77(3): 296 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
I. Sziller, D. Nguyen, A. Halmos, P. Hupuczi, Z. Papp, and S. S. Witkin
An A>G polymorphism at position -670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction
Mol. Hum. Reprod., March 1, 2005; 11(3): 207 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. R. Gingeras, R. Higuchi, L. J. Kricka, Y.M. D. Lo, and C. T. Wittwer
Fifty Years of Molecular (DNA/RNA) Diagnostics
Clin. Chem., March 1, 2005; 51(3): 661 - 671.
[Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
F. Z. Bischoff, D. E. Lewis, and J. L. Simpson
Cell-free fetal DNA in maternal blood: kinetics, source and structure
Hum. Reprod. Update, January 1, 2005; 11(1): 59 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
X. Y. Zhong, Y. Wang, S. Chen, Labu, Pubuzhuoma, Gesangzhuogab, Ouzhuwangmu, X. Pan, N. Zhu, C. Hahn, et al.
Circulating Fetal DNA in Maternal Plasma Is Increased in Pregnancies at High Altitude and Is Further Enhanced by Preeclampsia
Clin. Chem., December 1, 2004; 50(12): 2403 - 2405.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. K. Gupta, W. Holzgreve, B. Huppertz, A. Malek, H. Schneider, and S. Hahn
Detection of Fetal DNA and RNA in Placenta-Derived Syncytiotrophoblast Microparticles Generated in Vitro
Clin. Chem., November 1, 2004; 50(11): 2187 - 2190.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Farina, C. W.M. Chan, R. W.K. Chiu, N. B.Y. Tsui, P. Carinci, M. Concu, I. Banzola, N. Rizzo, and Y.M. D. Lo
Circulating Corticotropin-Releasing Hormone mRNA in Maternal Plasma: Relationship with Gestational Age and Severity of Preeclampsia
Clin. Chem., October 1, 2004; 50(10): 1851 - 1854.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Ding, R. W. K. Chiu, T. K. Lau, T. N. Leung, L. C. Chan, A. Y. Y. Chan, P. Charoenkwan, I. S. L. Ng, H.-y. Law, E. S. K. Ma, et al.
MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
PNAS, July 20, 2004; 101(29): 10762 - 10767.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
N B Y Tsui, S S C Chim, R W K Chiu, T K Lau, E K O Ng, T N Leung, Y K Tong, K C A Chan, and Y M D Lo
Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling
J. Med. Genet., June 1, 2004; 41(6): 461 - 467.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y. Li, B. Zimmermann, C. Rusterholz, A. Kang, W. Holzgreve, and S. Hahn
Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms
Clin. Chem., June 1, 2004; 50(6): 1002 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. J.P. Rijnders, G. C.M.L. Christiaens, A. A. Soussan, C. E. van der Schoot, P. Invernizzi, G. Simoni, and M. Podda
Cell-Free Fetal DNA Is Not Present in Plasma of Nonpregnant Mothers * Authors of the article cited above respond:
Clin. Chem., March 1, 2004; 50(3): 679 - 681.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. H. Rainer, N. Y.L. Lam, N. B.Y. Tsui, E. K.O. Ng, R. W.K. Chiu, G. M. Joynt, and Y.M. D. Lo
Effects of Filtration on Glyceraldehyde-3-Phosphate Dehydrogenase mRNA in the Plasma of Trauma Patients and Healthy Individuals
Clin. Chem., January 1, 2004; 50(1): 206 - 208.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Sekizawa, A. Farina, Y. Sugito, R. Matsuoka, M. Iwasaki, H. Saito, and T. Okai
Proteinuria and Hypertension Are Independent Factors Affecting Fetal DNA Values: A Retrospective Analysis of Affected and Unaffected Patients
Clin. Chem., January 1, 2004; 50(1): 221 - 224.
[Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Y. Li, X. Y. Zhong, A. Kang, C. Troeger, W. Holzgreve, and S. Hahn
Inability to Detect Cell Free Fetal DNA in the Urine of Normal Pregnant Women nor in Those Affected by Preeclampsia Associated HELLP Syndrome
Reproductive Sciences, December 1, 2003; 10(8): 503 - 508.
[Abstract] [PDF]

Home page
 Clin. Chem.Home page
Y. Sugito, A. Sekizawa, A. Farina, Y. Yukimoto, H. Saito, M. Iwasaki, N. Rizzo, and T. Okai
Relationship between Severity of Hyperemesis Gravidarum and Fetal DNA Concentration in Maternal Plasma
Clin. Chem., October 1, 2003; 49(10): 1667 - 1669.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Y.L. Lam, T. H. Rainer, L. Y.S. Chan, G. M. Joynt, and Y.M. D. Lo
Time Course of Early and Late Changes in Plasma DNA in Trauma Patients
Clin. Chem., August 1, 2003; 49(8): 1286 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. K.O. Ng, T. N. Leung, N. B.Y. Tsui, T. K. Lau, N. S. Panesar, R. W.K. Chiu, and Y.M. D. Lo
The Concentration of Circulating Corticotropin-releasing Hormone mRNA in Maternal Plasma Is Increased in Preeclampsia
Clin. Chem., May 1, 2003; 49(5): 727 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. K. O. Ng, N. B. Y. Tsui, T. K. Lau, T. N. Leung, R. W. K. Chiu, N. S. Panesar, L. C. W. Lit, K.-W. Chan, and Y. M. D. Lo
From the Cover: mRNA of placental origin is readily detectable in maternal plasma
PNAS, April 15, 2003; 100(8): 4748 - 4753.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
L. Y.S. Chan, T. N. Leung, K.C. A. Chan, H.-L. Tai, T. K. Lau, E. M.C. Wong, and Y.M. D. Lo
Serial Analysis of Fetal DNA Concentrations in Maternal Plasma in Late Pregnancy
Clin. Chem., April 1, 2003; 49(4): 678 - 680.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. M. Angert, E. S. LeShane, Y.M. D. Lo, L. Y.S. Chan, L. C. Delli-Bovi, and D. W. Bianchi
Fetal Cell-free Plasma DNA Concentrations in Maternal Blood Are Stable 24 Hours after Collection: Analysis of First- and Third-Trimester Samples
Clin. Chem., January 1, 2003; 49(1): 195 - 198.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
T.-W. Lau, T. N. Leung, L. Y.S. Chan, T. K. Lau, K.C. A. Chan, W. H. Tam, and Y.M. D. Lo
Fetal DNA Clearance from Maternal Plasma Is Impaired in Preeclampsia
Clin. Chem., December 1, 2002; 48(12): 2141 - 2146.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
I. Hoesli, M. Danek, D. Lin, Y. Li, S. Hahn, and W. Holzgreve
Circulating Erythroblasts in Maternal Blood Are Not Elevated Before Onset of Preterm Labor
Obstet. Gynecol., November 1, 2002; 100(5): 992 - 996.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. C. Lambert, Y. M. D. Lo, T. D. Erickson, T. S. Tylee, K. A. Guthrie, D. E. Furst, and J. L. Nelson
Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer
Blood, September 26, 2002; 100(8): 2845 - 2851.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
X. Y. Zhong, W. Holzgreve, and S. Hahn
Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts
Mol. Hum. Reprod., September 1, 2002; 8(9): 864 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. W. Swinkels, J. B. de Kok, J. C.M. Hendriks, E. Wiegerinck, P. L.M. Zusterzeel, and E. A.P. Steegers
Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome as a Complication of Preeclampsia in Pregnant Women Increases the Amount of Cell-free Fetal and Maternal DNA in Maternal Plasma and Serum
Clin. Chem., April 1, 2002; 48(4): 650 - 653.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Sekizawa, M. Jimbo, H. Saito, M. Iwasaki, Y. Sugito, Y. Yukimoto, J. Otsuka, and T. Okai
Increased Cell-free Fetal DNA in Plasma of Two Women with Invasive Placenta
Clin. Chem., February 1, 2002; 48(2): 353 - 354.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y. Ohashi, N. Miharu, H. Honda, O. Samura, and K. Ohama
Correlation of Fetal DNA and Human Chorionic Gonadotropin Concentrations in Second-Trimester Maternal Serum
Clin. Chem., February 1, 2002; 48(2): 386 - 388.
[Full Text] [PDF]

Home page
 NeoReviewsHome page
A. Stevens and J. L. Nelson
Maternal and Fetal Microchimerism: Implications for Human Diseases
NeoReviews, January 1, 2002; 3(1): e11 - 19.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Sekizawa, Y. Sugito, M. Iwasaki, A. Watanabe, M. Jimbo, S. Hoshi, H. Saito, and T. Okai
Cell-free Fetal DNA Is Increased in Plasma of Women with Hyperemesis Gravidarum
Clin. Chem., December 1, 2001; 47(12): 2164 - 2165.
[Full Text] [PDF]

Home page
 Obstet GynecolHome page
B. Pertl and D. W. Bianchi
Fetal DNA in Maternal Plasma: Emerging Clinical Applications
Obstet. Gynecol., September 1, 2001; 98(3): 483 - 490.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Hahn, X. Yan Zhong, and W. Holzgreve
Quantification of Circulating DNA: In the Preparation Lies the Rub
Clin. Chem., September 1, 2001; 47(9): 1577 - 1578.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. W. K. Chiu, L. L. M. Poon, T. K. Lau, T. N. Leung, E. M. C. Wong, and Y. M. D. Lo
Effects of Blood-Processing Protocols on Fetal and Total DNA Quantification in Maternal Plasma
Clin. Chem., September 1, 2001; 47(9): 1607 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
H. Honda, N. Miharu, Y. Ohashi, and K. Ohama
Successful Diagnosis of Fetal Gender Using Conventional PCR Analysis of Maternal Serum
Clin. Chem., January 1, 2001; 47(1): 41 - 46.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. N. Leung, J. Zhang, T. K. Lau, L. Y.S. Chan, and Y.M. D. Lo
Increased Maternal Plasma Fetal DNA Concentrations in Women Who Eventually Develop Preeclampsia.
Clin. Chem., January 1, 2001; 47(1): 137 - 139.
[Full Text] [PDF]

Home page
 Obstet GynecolHome page
X. Y. ZHONG, M. R. BURK, C. TROEGER, A. KANG, W. HOLZGREVE, and S. HAHN
Fluctuation of Maternal and Fetal Free Extracellular Circulatory DNA in Maternal Plasma
Obstet. Gynecol., December 1, 2000; 96(6): 991 - 996.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y.M. D. Lo
Fetal DNA in Maternal Plasma: Biology and Diagnostic Applications
Clin. Chem., December 1, 2000; 46(12): 1903 - 1906.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y.M. D. Lo, T. K. Lau, L. Y.S. Chan, T. N. Leung, and A. M.Z. Chang
Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA
Clin. Chem., September 1, 2000; 46(9): 1301 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Al-Mufti, H. Hambley, G. Albaiges, C. Lees, and K. H. Nicolaides
Increased fetal erythroblasts in women who subsequently develop pre-eclampsia
Hum. Reprod., July 1, 2000; 15(7): 1624 - 1628.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. L.S. Tang, T. N. Leung, J. Zhang, T. K. Lau, and Y.M. D. Lo
Detection of Fetal-derived Paternally Inherited X-Chromosome Polymorphisms in Maternal Plasma
Clin. Chem., November 1, 1999; 45(11): 2033 - 2035.
[Full Text] [PDF]

Home page
 Clin. Chem.