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Clinical Chemistry 46: 934-938, 2000;
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(Clinical Chemistry. 2000;46:934-938.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population

Winston L. Hutchinson1,1, Wolfgang Koenig2, Margit Fröhlich2, Malte Sund3, Gordon D.O. Lowe4 and Mark B. Pepys1,1,a

1 Immunological Medicine Unit, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom.

2 Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, D-89081 Ulm, Germany.

3 GSF-National Research Center for Environment and Health, MEDIS-Institute, D-85764 Neuherberg, Germany.

4 Department of Medicine, Royal Infirmary, Glasgow G312ER, United Kingdom.
a Address correspondence to this author at: Department of Medicine, Royal Free and University College Medical School, Rowland Hill St., London NW3 2PF, United Kingdom. Fax 44-20-7433-2803; e-mail m.pepys{at}rfc.ucl.ac.uk

Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection.

Methods: A robust new polyclonal-monoclonal solid- phase IRMA for CRP was developed, with a range of 0.05–10.0 mg/L.

Results: Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25–74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25–64 years) were very similar. The median CRP approximately doubled with age, from ~1 mg/L in the youngest decade to ~2 mg/L in the oldest, and tended to be higher in females.

Conclusion: This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations.




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