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Clinical Chemistry 46: 1041-1050, 2000;
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Right arrow Laboratory Management
Right arrow Evidence Based Laboratory Medicine and Test Utilization
(Clinical Chemistry. 2000;46:1041-1050.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Evidence-based Laboratory Medicine: Supporting Decision-Making

Christopher P. Price1

1 Department of Clinical Biochemistry, St. Bartholomew’s and The Royal London School of Medicine & Dentistry, Turner Street, London E1 2AD, United Kingdom. Fax 44-20-7377-1544; e-mail c.p.price{at}mds.qmw.ac.uk

There is an implicit acceptance that an evidence-based culture underpins the practice of laboratory medicine, in part because it is perceived as the scientific foundation of medicine. However, several reviews of specific test procedures or technologies have shown that the evidence base is limited and in many cases flawed. One of the key deficiencies in the scientific literature on diagnostic tests often is the absence of an explicit statement of the clinical need, i.e., the clinical or operational question that the use of the test is seeking to answer. Several reviews of the literature on specific procedures have also demonstrated that the experimental methodology used is flawed with, in some cases, significant bias being introduced. Despite these limitations it is recognized that a more evidence-based approach will help in the education and training of health professionals, in the creation of a research agenda, in the production of guidelines, in the support of clinical decision-making, and in resource allocation. Furthermore, as knowledge and technologies continue to be developed, an evidence-based strategy will be critical to harnessing these developments.




The following articles in journals at HighWire Press have cited this article:


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R. Rej
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B. Lumbreras-Lacarra, J. M. Ramos-Rincon, and I. Hernandez-Aguado
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Clin. Chem., March 1, 2004; 50(3): 530 - 536.
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C. Sturgeon
Practice Guidelines for Tumor Marker Use in the Clinic
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C. P Price
Regular review: Point of care testing
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