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Clinical Chemistry 46: 1395-1400, 2000;
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(Clinical Chemistry. 2000;46:1395-1400.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Reminders of Drug Effects on Laboratory Test Results

Marita Kailajärvi1,a, Timo Takala1, Paula Grönroos1, Nils Tryding3, Jorma Viikari2, Kerttu Irjala1 and Jari Forsström4

1 Central Laboratory and
2 Department of Medicine, Turku University Central Hospital, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland.

3 Box 57, SE-29621 Åhus, Sweden.

4 Medical Informatics Research Centre in Turku (MIRCIT), Kiinamyllynkatu 4–8, FIN-20520 Turku, Finland.
a Author for correspondence. Fax 358-2-261 3924; e-mail marita. kailajarvi{at}utu.fi

Drug effects on laboratory test results are difficult to take into account without an online decision support system. In this study, drug effects on hormone test results were coded using a drug-laboratory effect (DLE) code. The criteria that trigger the reminders were defined. To issue reminders, it was necessary to write a computer program linking the DLE knowledge base with databases containing individual patient medication and laboratory test results. During the first 10 months, 11% of the results from hormone samples were accompanied by one or more DLE reminders. The most common drugs to trigger reminders were glucocorticoids, furosemide, and metoclopramide. Physicians facing the reminders completed a questionnaire on the usefulness of the reminders. All respondents considered them useful. In addition, DLE reminders had caused 74% of respondents to refrain from additional, usually performed examinations. In conclusion, drug effects on laboratory tests should always be considered when interpreting laboratory results. An online reminder system is useful in displaying potential drug effects alongside test results.




The following articles in journals at HighWire Press have cited this article:


Home page
 Arch Intern MedHome page
G. D. Schiff, D. Klass, J. Peterson, G. Shah, and D. W. Bates
Linking Laboratory and Pharmacy: Opportunities for Reducing Errors and Improving Care
Arch Intern Med, April 28, 2003; 163(8): 893 - 900.
[Abstract] [Full Text] [PDF]


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