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Clinical Chemistry 9: 566-572, 1963;
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Clinical Chemistry, Vol 9, 566-572, Copyright © 1963 by the American Association for Clinical Chemistry

Metabolic Disorders Leading to Mental Deficiency

II. Screening for Excessive Urinary Excretion of Nonurea Organic Carbon and Nitrogen

J. L. Karlsson 1

1 Sonoma State Hospital, Eldridge, Calif.

A new approach is described for the detection of abnormal metabolites in the urine of patients with known or suspected metabolic disorders. Distribution curves are presented for nonurea organic carbon and nitrogen which form a basis for judging whether grossly abnormal amounts of organic materials are present in the urine.

Families with recurrent mental retardation have been identified whose mental defect may be on an unknown metabolic basis.

Submitted on March 30, 1962







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Copyright © 1963 by the American Association for Clinical Chemistry.