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Clinical Chemistry 43: 2202-2204, 1997;
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(Clinical Chemistry. 1997;43:2202-2204.)
© 1997 American Association for Clinical Chemistry, Inc.

Technical Briefs

Stability of a Control Material Suitable for Quantitative Measurement of Urine Myoglobin

Kenneth R. Copeland, Bounthon Loun and Frank A. Sedora

Dept. of Pathol., Div. of Clin. Labs., Duke Univ. Med. Center, Durham, NC 27710
a author for correspondence: fax 919-681-7786, e-mail sedor003@mc.duke.edu

Myoglobin is a 17-kDa single-chain hemoprotein found in skeletal and cardiac muscle. This heme protein facilitates the movement of oxygen into cells and provides for local storage of oxygen. Myoglobin is found in the circulation as a result of muscle damage. Several conditions are associated with the release of myoglobin into the circulation, including myocardial infarction, trauma, ischemia, surgery, exercise, rhabdomyolysis, and other myopathy-associated disease states [1–3].

The quantitative measurement of myoglobin in urine is clinically important in diagnosing myoglobinuria, which can subsequently induce acute renal failure, particularly in posttrauma, surgery, and rhabdomyolysis patients. Recent studies have suggested that patients with a urine myoglobin concentration >20 000 µg/L, particularly with a decreased myoglobin clearance rate (<4 mL/min), are at increased risk for decreased renal function (4)(5). Although the mechanism for myoglobin-induced acute renal failure has not yet been elucidated, large amounts of myoglobin present in the tubules may precipitate, particularly under acidic conditions, resulting in increased intratubular pressure and, subsequently, the decreased glomerular filtration rate (6) and (or) free-radical generation from inorganic iron may cause renal damage (7). The identification of the early clinical sequelae of myoglobinuria is important for enabling administration of prophylactic treatment for acute renal failure (8).

. . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.