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Clinical Chemistry 43: 2440-2441, 1997;
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(Clinical Chemistry. 1997;43:2440-2441.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Increased Plasma Endothelin-1 After Nicotine Consumption in Nonsmokers

Claudio Letiziaa, Sabrina Cerci, Stefano Subioli, Luigi Scuro and Giovanni Clemente

2nd Dept. of Intern. Med., University of Rome "La Sapienza", Rome, Italy
a Address correspondence to this author, at: 2a Clinica Medica, Policlinico Umberto I, 00185 Rome, Italy.


To the Editor:

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide originally isolated from the supernatant of cultured porcine endothelial cells (1). ET-1 has not only contractile effects but also growth effects on both smooth muscle and heart muscle cells in vitro (2). Studies have shown that some substances (1)(3), e.g., vasopressin (4), stimulate the release of immunoreactive ET-1 from cultured bovine carotid endothelial cells.

Smoking is known to induce a variety of effects in the cardiovascular and hormonal systems in humans (5)(6)(7)(8)(9)(10). Administration of nicotine causes the release of some hormones (9)(10) and produces increases in blood pressure, heart rate, cardiac output, and oxygen consumption (5)(6)(7)(8). Recently, Yildiz et al. (11) reported that heavy cigarette smokers had higher plasma ET-1 concentrations than either light smokers or controls. In another study, Haak et al. (. . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.