Clinical Chemistry Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 43: 2441-2443, 1997;
This Article
Right arrow Full Text
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alberty, R.
Right arrow Articles by Albertyová, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alberty, R.
Right arrow Articles by Albertyová, D.
Related Collections
Right arrow Laboratory Management
(Clinical Chemistry. 1997;43:2441-2443.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Biological Variation of Free and Total Carnitine in Serum of Healthy Subjects

Roman Alberty1,a and Dása Albertyová

1 Dept. of Biol., Mathias Belius Univ., Tajovského 40, 974 01 Banská Bystrica, Slovak Republic
Dept. of Clin. Biochem., F.D. Roosevelt Hosp., Nám. L. Svobodu 1, 975 17 Banská Bystrica, Slovak Republic
a Author for correspondence.


To the Editor:

Determination of carnitine (L-ß-hydroxy-{gamma}-trimethylaminobutyric acid) in biological samples plays an important role in the diagnosis of diseases with carnitine deficiency (1). In the past few years, and also in this Journal, several spectrophotometric methods for assaying carnitine in serum have been described (2)(3)(4)(5)(6). To our knowledge, however, no data have been published on the biological variation of this serum analyte.

For any new test, data on the biological variation generated from the healthy population may be used (a) in setting desirable performance standards or analytical goals, (b) in assessing the utility of conventional population-based reference intervals, and (c) in critically evaluating the significance of changes in serial results from an individual (7).

To investigate the analytical and biological variation of free and total carnitine, as well as of the acyl/free carnitine ratio, we collected blood samples once a week for 4 weeks from each of 14 healthy subjects (7 men and 7 nonpregnant women, ages 21–23 years), students of Mathias Belius University. The subjects agreed to maintain current dietary habits, body weight, and exercise program (if any) for the duration of the study. The criteria of the hospital Ethics Committee were respected in this experiment.

To minimize sources of preanalytical variation, venous blood specimens were drawn between 0800 and 0900 h after ~12 . . . [Full Text of this Article]


Acknowledgments


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Circ. Res.Home page
Z. Dagher, N. Ruderman, K. Tornheim, and Y. Ido
Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells
Circ. Res., June 22, 2001; 88(12): 1276 - 1282.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Association for Clinical Chemistry.