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Clinical Chemistry 43: 540-541, 1997;
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(Clinical Chemistry. 1997;43:540-541.)
© 1997 American Association for Clinical Chemistry, Inc.

Technical Briefs

Serum Neuron-Specific Enolase in Patients with Pituitary Adenoma

Hassan M. Heshmati1,a, Yvan Touitou2, Luc Foubert1, William F. Young, Jr.3, Eric Bruckert1 and Gérard Turpin1

1 Dept. of Endocrinol., Pitié Hospital, and
2 Dept. of Biochem., Pitié School of Medicine, 75013 Paris, France;
3 Div. of Endocrinol., Mayo Clinic and Mayo Foundation, Rochester, MN 55905;
a address for correspondence: Endocrine Res. Unit, 5–164 West Joseph, Mayo Clinic, Rochester, MN 55905: fax 507-255-4828, e-mail heshh@mayo.edu

Neuron-specific enolase (NSE) is an isomer of the widely distributed glycolytic enzyme 2-phospho-D-glycerate hydrolase (EC 4.2.1.11), composed of two subunits, {alpha} and {gamma}. NSE is localized in neurons and in peripheral and central neuroendocrine cells ["amine precursor uptake and decarboxylation" cells (APUD)] (1). Tumors arising from APUD cells may contain high amounts of NSE detectable by both immunostaining of tumor cells and radioimmunological measurement of extractable enzyme (2)(3). These tumors include small-cell lung cancer (4)(5), neuroblastoma (6), pancreatic islet cell cancer (7), . . . [Full Text of this Article]


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