Clinical Chemistry Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 43: 543-545, 1997;
This Article
Right arrow Full Text
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cioffi, M.
Right arrow Articles by Puca, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cioffi, M.
Right arrow Articles by Puca, G. A.
Related Collections
Right arrow Laboratory Management
Right arrow Pediatric Clinical Chemistry
Right arrow Proteomics and Protein Markers
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 1997;43:543-545.)
© 1997 American Association for Clinical Chemistry, Inc.

Technical Briefs

Serum Osteocalcin in 1634 Healthy Children

Michele Cioffia, Anna Maria Molinari, Patrizia Gazzerro, Bruno Di Finizio, Mario Fratta, Angela Deufemia and Giovanni Alfredo Puca

Ist. di Patol. Generale e Oncol., Seconda Univ. degli Studi di Napoli, Larghetto S. Aniello a Caponapoli, 2, 80138 Napoli, Italy;
a author for correspondence: fax +81/566-5695

Osteocalcin or bone Gla protein (BGP) is a vitamin K-dependent, low-molecular-mass (5800 Da), 49 amino acid peptide synthesized by osteoblasts (1)(2). Osteocalcin contains three residues of {gamma}-carboxyglutamate, which provide the point of interaction between the BGP and hydroxyapatite in the extracellular bone matrix. The 19–20 and 43–44 residues provide sites for the tryptic hydrolysis; the resulting peptides may be the products of liver, kidney, and plasmatic breakdown of the molecule. The physiological role of these fragments is unknown.

Osteocalcin is an important marker of bone turnover in physiological and pathological conditions (3). Physiologically, serum osteocalcin was increased in children, particularly during the first year of life and during puberty, when the evolution of the concentration was related to the rapidity of physical growth. The significant correlation between BGP and testosterone and serum insulin-like growth factor 1 is consistent . . . [Full Text of this Article]


Acknowledgments


References




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. Rauchenzauner, A. Schmid, P. Heinz-Erian, K. Kapelari, G. Falkensammer, A. Griesmacher, G. Finkenstedt, and W. Hogler
Sex- and Age-Specific Reference Curves for Serum Markers of Bone Turnover in Healthy Children from 2 Months to 18 Years
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 443 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.-S. Tsai, M.-H. Jang, S. H.-J. Hsu, W.-C. Cheng, and M.-H. Chang
Bone Alkaline Phosphatase Isoenzyme and Carboxy-Terminal Propeptide of Type-I Procollagen in Healthy Chinese Girls and Boys
Clin. Chem., January 1, 1999; 45(1): 136 - 138.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Association for Clinical Chemistry.