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Technical Briefs |
Serv. de Bioquím., Hosp. Univ. Sant Joan de Déu, Passeig de Sant Joan de Dé 2, 08950-Esplugues (Barcelona), Spain
a author for correspondence: fax 34-3-2803626
Determination of plasma total homocysteine (tHcy; the sum of all forms of thiol derivatives that form homocysteine by reduction) (1) is essential for diagnosis and follow-up of homocystinuric patients (2) and for detection of moderate hyperhomocysteinemia, a risk factor for coronary, cerebral, and peripheral vascular disease (3). In childhood, moderate hyperhomocysteinemia may result from several genetic, nutritional (4), and iatrogenic factors (1), renal failure (5), HIV (6), and cancer (1). Plasma tHcy in children may be a useful biochemical marker for a genetic risk of premature atherosclerosis (1).
Various methods to measure tHcy have been described during the last decade, but HPLC with fluorescence detection is the most common (4)(7). Age- and sex-specific reference intervals for adults have been reported (4), considering even vitamin status (8), but data for children are sparse and inconsistent [9, 10], and no evidence is available in Mediterranean countries, where dietary vitamin content differs from that in Northern Europe or North America.
Our goal was to establish reference values for a pediatric population
in our geographical area with our working conditions so that we could
compare the values
References
The following articles in journals at HighWire Press have cited this article:
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  A.-L. Bjorke-Monsen, I. Torsvik, H. Saetran, T. Markestad, and P. M. Ueland Common Metabolic Profile in Infants Indicating Impaired Cobalamin Status Responds to Cobalamin Supplementation Pediatrics, July 1, 2008; 122(1): 83 - 91. [Abstract] [Full Text] [PDF]
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 S. Kurul, A. Unalp, and U. Yis Homocysteine Levels in Epileptic Children Receiving Antiepileptic Drugs J Child Neurol, December 1, 2007; 22(12): 1389 - 1392. [Abstract] [PDF]
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 C. T. White, P. Trnka, and D. G. Matsell Selected Primary Care Issues and Comorbidities in Children Who Are on Maintenance Dialysis: A Review for the Pediatric Nephrologist Clin. J. Am. Soc. Nephrol., July 1, 2007; 2(4): 847 - 857. [Abstract] [Full Text] [PDF]
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 C. Dou, D. Xia, L. Zhang, X. Chen, P. Flores, A. Datta, and C. Yuan Development of a Novel Enzymatic Cycling Assay for Total Homocysteine Clin. Chem., October 1, 2005; 51(10): 1987 - 1989. [Full Text] [PDF]
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W.-H. Tan, F. S. Eichler, S. Hoda, M. S. Lee, H. Baris, C. A. Hanley, P. E. Grant, K. S. Krishnamoorthy, and V. E. Shih Isolated Sulfite Oxidase Deficiency: A Case Report With a Novel Mutation and Review of the Literature Pediatrics, September 1, 2005; 116(3): 757 - 766. [Abstract] [Full Text] [PDF]
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 I. M van Beynum, M. den Heijer, C. M. Thomas, L. Afman, D. Oppenraay-van Emmerzaal, and H. J Blom Total homocysteine and its predictors in Dutch children Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1110 - 1116. [Abstract] [Full Text] [PDF]
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 S Haywood, R Liesner, S Pindora, and V Ganesan Thrombophilia and first arterial ischaemic stroke: a systematic review Arch. Dis. Child., April 1, 2005; 90(4): 402 - 405. [Abstract] [Full Text] [PDF]
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 C. Papoutsakis, N. Yiannakouris, Y. Manios, E. Papaconstantinou, F. Magkos, K. H. Schulpis, A. Zampelas, and A. L. Matalas Plasma Homocysteine Concentrations in Greek Children Are Influenced by an Interaction between the Methylenetetrahydrofolate Reductase C677T Genotype and Folate Status J. Nutr., March 1, 2005; 135(3): 383 - 388. [Abstract] [Full Text] [PDF]
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A. Bowron, A. Barton, J. Scott, and D. Stansbie Blood Spot Homocysteine: A Feasibility and Stability Study Clin. Chem., January 1, 2005; 51(1): 257 - 258. [Full Text] [PDF]
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 T. Szamosi, E. Roth, T. Szamosi Jr, E. Tomsits, A. Tordai, and T. Szabo Hyperhomocysteinemia, Enzyme Polymorphism and Thiobarbituric Acid Reactive System in Children with High Coronary Risk Family History J. Am. Coll. Nutr., October 1, 2004; 23(5): 386 - 390. [Abstract] [Full Text] [PDF]
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 I. Baric, K. Fumic, B. Glenn, M. Cuk, A. Schulze, J. D. Finkelstein, S. J. James, V. Mejaski-Bosnjak, L. Pazanin, I. P. Pogribny, et al. S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism PNAS, March 23, 2004; 101(12): 4234 - 4239. [Abstract] [Full Text] [PDF]
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A.-L. B. Monsen, H. Refsum, T. Markestad, and P. M. Ueland Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups from 4 Days to 19 Years Clin. Chem., December 1, 2003; 49(12): 2067 - 2075. [Abstract] [Full Text] [PDF]
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A. Must, P. F. Jacques, G. Rogers, I. H. Rosenberg, and J. Selhub Serum Total Homocysteine Concentrations in Children and Adolescents: Results from the Third National Health and Nutrition Examination Survey (NHANES III) J. Nutr., August 1, 2003; 133(8): 2643 - 2649. [Abstract] [Full Text] [PDF]
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A. L. Bjorke Monsen and P. M. Ueland Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence Am. J. Clinical Nutrition, July 1, 2003; 78(1): 7 - 21. [Abstract] [Full Text] [PDF]
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L. M Rogers, E. Boy, J. W Miller, R. Green, J. C. Sabel, and L. H Allen High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations Am. J. Clinical Nutrition, February 1, 2003; 77(2): 433 - 440. [Abstract] [Full Text] [PDF]
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J.-C. Minet, E. Bisse, C.-P. Aebischer, A. Beil, H. Wieland, and J. Lutschg Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates Am. J. Clinical Nutrition, September 1, 2000; 72(3): 751 - 757. [Abstract] [Full Text] [PDF]
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E. Cardo, E. Monros, C. Colome, R. Artuch, J. Campistol, M. Pineda, and M. A. Vilaseca Children With Stroke: Polymorphism of the MTHFR Gene, Mild Hyperhomocysteinemia, and Vitamin Status J Child Neurol, May 1, 2000; 15(5): 295 - 298. [Abstract] [PDF]
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C. De Laet, J.-C. Wautrecht, D. Brasseur, M. Dramaix, J.-M. Boeynaems, J. Decuyper, and A. Kahn Plasma homocysteine concentrations in a Belgian school-age population Am. J. Clinical Nutrition, May 1, 1999; 69(5): 968 - 972. [Abstract] [Full Text] [PDF]
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 S. K. Osganian, M. J. Stampfer, D. Spiegelman, E. Rimm, J. A. Cutler, H. A. Feldman, D. H. Montgomery, L. S. Webber, L. A. Lytle, L. Bausserman, et al. Distribution of and Factors Associated With Serum Homocysteine Levels in Children: Child and Adolescent Trial for Cardiovascular Health JAMA, April 7, 1999; 281(13): 1189 - 1196. [Abstract] [Full Text] [PDF]
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P. F Jacques, I. H Rosenberg, G. Rogers, J. Selhub, B. A Bowman, E. W Gunter, J. D Wright, and C. L Johnson Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey Am. J. Clinical Nutrition, March 1, 1999; 69(3): 482 - 489. [Abstract] [Full Text] [PDF]
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M. A. Vilaseca, D. Moyano, R. Artuch, I. Ferrer, M. Pineda, E. Cardo, J. Campistol, C. Pavia, and J.-A. Camacho Selective Screening for Hyperhomocysteinemia in Pediatric Patients Clin. Chem., March 1, 1998; 44(3): 662 - 664. [Full Text] [PDF]
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