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Clinical Chemistry 43: 698-699, 1997;
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(Clinical Chemistry. 1997;43:698-699.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Detection by 1H-NMR Spectroscopy of Chloroquine in Urine from Acutely Poisoned Patient

Susanna Maschke1,a, Nathalie Azaroual3, Jean-Michel Wieruszeski4, Guy Lippens4, Michel Imbenotte5, Daniel Mathieu2, Gaston Vermeersch3 and Michel Lhermitte1,5

1 Lab. de Biochim.

2 Service de Réanimation, Hôpital Calmette, CHR et U de Lille, Bd. du Pr. J.Leclerc, 59037 Lille Cedex, France,
3 Lab. de Phys., URA CNRS 351, Lab. d'Application RMN de L'Université de Lille II, BP 83, 59006 Lille Cedex

4 Lab. de Chim. des Biomolécules, URA CNRS 1309, Institut Pasteur de Lille, 1 rue du Pr. Calmette, BP 245, 59019 Lille Cedex

5 Lab. de Toxicol., Faculté des Sci. Pharm. et Biol. de Lille, BP 83, 59006 Lille Cedex
a Author for correspondence.


To the Editor:

High-resolution NMR spectroscopy is increasingly being used to analyze a variety of physiological fluids (1)(2) and may constitute a new tool in clinical diagnosis. Many important low-molecular-mass metabolites can be readily detected and quantified by 1H-NMR. New sequences, such as 1H–1H J-resolved map, have proved very useful (3). We have used these methods to investigate a urine sample obtained in a case of acute chloroquine poisoning.

A 41-year-old man was admitted to the hospital after attempting suicide. He was conscious, without neurological deficit; the electrocardiogram showed an increased QT duration, and his blood potassium concentration was 3 mmol/L. A toxicological screen was requested and reported a plasma chloroquine concentration of 890 µg/L.

For NMR measurements, we used a urine sample collected at admission. Spectra were recorded at 300 MHz with a . . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.