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Clinical Chemistry 43: 855a-856a, 1997;
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(Clinical Chemistry. 1997;43:855A-856.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Reduced Serum Antioxidant Capacity In Healthy Centenarians

Pamela Pinzani1,a, Enrico Petruzzi3, Claudio Orlando1, AnaMaria Stefanescu1, Mario Francesco Antonini3, Mario Serio2 and Mario Pazzagli1

1 Clin. Biochem. and
2 Endocrinol. Unit, Dept. of Clin. Pathophysiol., Viale Pieraccini, 6, 50139 Florence, Italy,
3 Inst. of Gerontol. and Geriatrics, Univ. of Florence, 50139 Florence, Italy
a Author for correspondence.


To the Editor:

Free radicals are considered important factors in biological aging (1). Consequently, there is increasing interest in the mechanisms of antioxidant protection against free-radical-induced injury and in identification of suitable biochemical indicators for measuring serum antioxidant capacity (SAC) (2). Several methods have been proposed for the measurement of SAC, including the enhanced chemiluminescence assay used in this study (3). This technique is calibrated with TroloxTM, a water-soluble vitamin E analog (Hoffmann–La Roche, obtained from Aldrich Chemical Co., Gillingham, Dorset, UK), and assay results are expressed as µmol/L Trolox equivalents.

We measured serum SAC in 58 healthy subjects: 37 adults (19 men and 18 women, age range 18–91 years) and . . . [Full Text of this Article]


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