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Clinical Chemistry 43: 857-859, 1997;
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(Clinical Chemistry. 1997;43:857-859.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Polymorphonuclear Elastase and Interleukin-6 in Amniotic Fluid in Preterm Labor

Adriana Rivero-Marcotegui1,a, Carlos Larrañaga-Azcárate2, Rafael Ceres-Ruiz2 and Sergio García-Merlo1

1 Serv. de Bioquím. Clín., Hosp. de Navarra, C/Iruñlarrea 3, Pamplona 31008, Spain,
2 Serv. de Ginecol. y Obstet., Hosp. Virgen del Camino, Pamplona, Spain
a Author for correspondence.


To the Editor:

Microbial invasion of the amniotic cavity has been demonstrated in 16.1% of women with preterm labor and intact membranes (1). This situation is frequently difficult to diagnose because its clinical manifestations occur late in pregnancy and because biochemical and microbiological studies are required for accurate diagnosis (2). Saito et al. (3) implicated cytokines in the pathophysiology of preterm labor, and high concentrations of interleukin-6 (IL-6) have been detected in amniotic fluid of women with amniotic infection (4). Moreover, we thought that a proteinase, e.g., elastase, located in the polymorphonuclear neutrophils (PMN) might be involved in infection-associated preterm labor. We therefore undertook a study of IL-6, elastase-PMN (which has not been studied before), leukocytes, and glucose concentrations in . . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.