Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 43: 860-861, 1997;
This Article
Right arrow Full Text
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roberts, W. L.
Right arrow Articles by Whitehair, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roberts, W. L.
Right arrow Articles by Whitehair, D.
Related Collections
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 1997;43:860-861.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Prevention of Analytical False-Positive Increases of Cardiac Troponin I on the Stratus II Analyzer

William L. Roberts1,a, Clay B. Calcote1, Barun K. De1, Vicki Holmstrom2, Cyndi Narlock2 and Fred S. Apple2,a

1 Dept. of Pathol., Univ. of Mississippi Med. Center, 2500 N. State St., Jackson, MS 39216,
2 Dept. of Pathol., Hennepin County Medical Center, 701 Park Ave., Minneapolis, MN 55415.
a Author correspondence.


To the Editor:

Cardiac troponin I (cTnI) is both highly sensitive and specific for the detection of myocardial injury (1)(2), and cTnI now challenges creatine kinase MB (CK-MB) as the optimal marker for acute myocardial infarction (3)(4). The Stratus II batch analyzer (Dade International, Miami, FL) uses monoclonal anti-cTnI antibodies immobilized on a glass fiber support for the measurement of serum or plasma cTnI. During the course of clinical evaluations and implementation of cTnI testing on the Stratus II, we noted occasional falsely high results on serum specimens that were found to be either within the reference interval or below the detection limit upon reanalysis. It appeared that incomplete clotting of the specimen contributed to false-positive cTnI values. This letter describes our efforts to eliminate these analytical false-positive cTnI results.

Results for cTnI on 20 serum specimens (2.2%) from >900 patient specimens tested over 3 months were challenged by clinicians as . . . [Full Text of this Article]


References

Debbie Whitehair

Dade International, Miami, FL \.
a Author correspondence.


To the Editor:




The following articles in journals at HighWire Press have cited this article:


Home page
 ChestHome page
C. Roongsritong, I. Warraich, and C. Bradley
Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction: Incidence and Clinical Significance
Chest, May 1, 2004; 125(5): 1877 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. Beyne, J.-P. Vigier, P. Bourgoin, and M. Vidaud
Comparison of Single and Repeat Centrifugation of Blood Specimens Collected in BD Evacuated Blood Collection Tubes Containing a Clot Activator for Cardiac Troponin I Assay on the ACCESS Analyzer
Clin. Chem., November 1, 2000; 46(11): 1869 - 1870.
[Full Text] [PDF]

Home page
 CirculationHome page
A. S. Jaffe, J. Ravkilde, R. Roberts, U. Naslund, F. S. Apple, M. Galvani, and H. Katus
It's Time for a Change to a Troponin Standard
Circulation, September 12, 2000; 102(11): 1216 - 1220.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. S. Ooi and A. A. House
Cardiac troponin T in hemodialyzed patients
Clin. Chem., July 1, 1998; 44(7): 1410 - 1416.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Association for Clinical Chemistry.