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Clinical Chemistry 43: 1672-1673, 1997;
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(Clinical Chemistry. 1997;43:1672-1673.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Relations between Intestinal Alkaline Phosphatase Activity and Insulin Secretion in Obese Patients

Agostino Ognibenea, Laura Pala1, Gianni Messeri2, Carlo Maria Rotella1 and Piero Berti

Clin. Chem. Lab.,
1 Lab. of Endocrinol. and Toxicol., Azienda Ospedaliera Careggi Firenze, Firenze, Italy,
2 Dept. of Clin. Pathophysiol., University of Firenze, Firenze, Italy
a Address correspondence to this author at: Lab. di Endocrinol., Azienda Ospedaliera Careggi, Largo Palagi 1, 50139 Firenze, Italia.


To the Editor:

Adult intestinal alkaline phosphatase (IAP) isoenzyme has long been known to be a minor component of serum alkaline phosphatase (ALP). On electrophoresis it migrates in the ß-globulin position and is detectable at low activity (<20% of total ALP) in ~20% of sera from healthy individuals (1). Increased IAP activity has been reported in chronic renal failure (55%), liver cirrhosis (46%), and diabetes (54%) (2). Moreover, subjects with blood groups O and B have also been reported to have increased serum IAP activity, especially in postprandial samples after a fatty meal (3). A high percentage . . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.