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Clinical Chemistry 45: 2027-2028, 1999;
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(Clinical Chemistry. 1999;45:2027-2028.)
© 1999 American Association for Clinical Chemistry, Inc.

Technical Briefs

Ascitic Fluid Interleukin-8 to Distinguish Spontaneous Bacterial Peritonitis and Sterile Ascites in Cirrhotic Patients

Cecília Martínez-Brú1,a, Cristina Gómez2, Mariano Cortés1, Germán Soriano2, Carlos Guarner2, Teresa Planella1 and Francesc González-Sastre1

1 Biochemistry and
2 Gastroenterology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain;
a address correspondence to this author at: Servei de Bioquímica, Hospital de la Santa Creu i Sant Pau, Avgda. Pare Claret 167, 08025 Barcelona, Spain

Spontaneous bacterial peritonitis (SBP) is a common and potentially fatal complication of cirrhosis. The pathogenesis of spontaneous ascitic fluid infection appears to involve translocation of bacteria from the gut to the mesenteric lymph nodes, depressed reticuloendothelial phagocytic activity, and deficient ascitic fluid antibacterial activity. A high index of suspicion of this infection and a low threshold for performing an abdominal paracentesis are required to detect infection early, when survival is most likely (1). Interleukin-8 (IL-8) is a cytokine produced by a variety of cells in response to stimuli, such as bacterial lipopolysaccharide, with a strong chemotactic activity on neutrophils. Increased plasma IL-8 has been observed in patients with severe infections as well as in alcoholic and nonalcoholic cirrhotic patients (2)(3). To our knowledge, IL-8 production in ascitic fluid in cirrhotic patients developing SBP has not been determined.

The aim of this study was to evaluate (a) IL-8 production in both . . . [Full Text of this Article]


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